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Resting Cell Potentials and the Neuron

The content delves into the intricacies of cell membrane potential, focusing on neurons, ion concentration differences, and the mechanisms that sustain the resting membrane potential. It also explores how these principles apply to neuronal action potentials and the impact of ion permeability changes.
  • Resting membrane potential is established by the difference in ion concentration inside and outside the cell, with the inside being more negative.
  • The sodium-potassium pump plays a crucial role in maintaining this potential by expelling three sodium ions for every two potassium ions it allows in, using one ATP in the process.
  • Ion movement across membranes is influenced by membrane permeability, ion concentration, and charge difference, with the Nernst equation and Goldman-Hodgkin-Katz equation providing mathematical models to describe these dynamics.
  • Neuronal action potentials are triggered when changes in ion permeability lead to depolarization that reaches a threshold, facilitating the transmission of signals.
  • Understanding how different ions affect membrane potential is essential, with chloride ions, for example, contributing to polarization rather than depolarization.
Understanding Resting Membrane Potential
The Role of the Sodium-Potassium Pump
Ion Movement and Membrane Permeability
Neuronal Action Potentials and Ion Permeability